Earlier today in an investor call with EA it's been confirmed that there will be more in the Dead Space franchise. Whether it's a third Dead Space which would make sense or rather who knows what. Could be something mobile for all we know. Specifically though it's been stated that it will be released during the publisher's 2013 fiscal year, which ends March 31st, 2013.
The investor call that unveiled this is below,
"At the foundation is another year of blockbuster brands: Madden NFL, FIFA, Sim City, Medal of Honor, Dead Space, and Need for Speed as well as mobile hits like The Simpsons Tapped Out, and Bejeweled," EA stated
Game Informer has gathered this after contacting a spokesman,
"There’s no further information today but watch for several big product announcements from EA at E3 in June."